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When Frank Lloyd Wright said that “a great architect is not made by way of a brain nearly so much as he is made by way of a cultivated, enriched heart,” surely he was alluding to the fact that travel and exploration are important aspects of any designer’s process. Seriously, what better way to feed your soul and get the creative juices flowing than a fabulous get-away in an inspiring and culturally significant hotel?

A testament to the splendor of heart-driven design, we’ve married two of our favorite things – extraordinary hotels and stunning architecture – to bring you our guide to the most architecturally significant hotels in the world. From Frank Gehry’s iridescent design set against a medieval backdrop in Spain’s Rioja wine region to a recently renovated mid-century icon by John Lautner to Renzo Piano’s whimsical update of an old Fiat factory in Italy, click through to check out these visionary and inspiring designs. Let us know in the comments which one you’ll be booking for your next creative crusade!

Hôtel Le Corbusier by Le Corbusier – Marseille, France

Image credit: Yesterday sucks

Hotel Marqués de Riscal by Frank Gehry – Elciego, Spain

Image credit: Hoosta Magazine; Hotel Marqués de Riscal

Hotel Lautner by John Lautner – Desert Hot Springs, California

Image credit: Hotel Lautner

Le Meridien Lingotto by Renzo Piano – Turin, Italy

Image credit: Le Meridien Hotels and Resorts

Hotel Parco dei Principi by Gio Ponto – Sorrento, Italy

Image credit: Royal Group Hotels & Resorts

Hotel Luzern by Jean Nouvel – Luzern, Switzerland

Image credit: DESIGN HOTELS

Inn at Price Tower by Frank Lloyd Wright – Bartlesville, Oklahoma

Image credit: Graela via archdaily; Price Tower Arts Center

Four Seasons by I.M. Pei – New York, New York

Image credit: bobistraveling; damn cool pictures

Hotel Gaudí by Antoni Gaudí – Barcelona, Spain

Image credit: Hotel Gaudí

Miramar Resort Hotel by Michael Graves – El Gouna, Egypt

Image credit: bustler